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Apr 17 - Researchers identify how eating a Western diet impairs memory functioning



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 1 month ago '16        #1
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00010111  topics gone triple plat - Number 1 spot x24
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icon Apr 17 - Researchers identify how eating a Western diet impairs memory functioning
 

 
In a recent study, researchers have shed light on how early consumption of a Western diet — characterized by high levels of processed foods, saturated fats, and simple sugars — can lead to lasting deficits in hippocampal-dependent episodic memory, despite not causing obesity or metabolic dysfunction.

This research emphasizes the critical role that diet plays in brain health, particularly during early developmental stages, and points towards acetylcholine signaling in the hippocampus as a potential mediator of these long-lasting memory impairments. The findings have been published in Brain, Behavior, and Immunity.

Previous research has found a connection between the consumption of a Western diet and various cognitive issues. However, what remained elusive was the mechanisms that could explain how these dietary habits lead to specific cognitive detriments, such as memory loss. The new study was motivated by the broader goal of contributing actionable insights into public health strategies aimed at preventing cognitive decline.

“In addition to promoting obesity and metabolic dysfunction, a diet high in saturated fat, added sugars, and processed foods can lead to memory impairments. We were interested in understanding the underlying neurobiological mechanisms for this connection,” said study author Scott E. Kanoski, a professor of human and evolutionary biology at the University of Southern California.

To explore the long-term effects of an early life Western diet on cognitive functions, the researchers turned to male Sprague Dawley rats, which were chosen for their well-documented responses in dietary and cognitive research.

The study commenced when the rats were on postnatal day 25, a critical period for development. The dietary regimen was designed to closely mimic the nutritional profile of a Western diet, characterized by high fat, high sugar, and processed foods. To achieve this, the researchers used a cafeteria-style diet model, providing rats with free-choice access to various high-fat, high-sugar foods, and drinks, alongside standard chow for control animals.

The researchers found that rats fed a Western diet during early development exhibited significant, long-lasting deficits in hippocampal-dependent episodic memory, which disruptions in hippocampal acetylcholine signaling acting as a potential mediator.

Acetylcholine is a critical neurotr@nsmitter for learning and memory processes, and its disruption has been linked to cognitive decline and conditions like Alzheimer’s disease. In the Western diet-fed rats, there were notable changes in acetylcholine neurotr@nsmission within the hippocampus, including altered dynamics of acetylcholine release during memory tasks and long-term reductions in cholinergic tone.

These findings point to a significant role of acetylcholine signaling in the observed cognitive deficits, suggesting that dietary influences on this neurotr@nsmitter system could underlie the lasting memory impairments.

The researchers also explored the role of the gut microbiome in mediating the cognitive effects of a Western diet. While early life consumption of this diet altered the gut microbiome, these changes were largely reversible with a subsequent healthy diet intervention. This reversibility of microbiome alterations, however, did not extend to the cognitive impairments, which persisted despite the dietary switch.

The findings indicate that “what types of food one consumes can have impacts on brain function throughout the lifespan, but particularly during early life periods when brain systems are still developing,” Kanoski told PsyPost. However, he noted that “these results come from rodents. While rodents are a good model for human physiology and metabolic function, more research is needed with regards to tr@nslational relevance.”

The study, “Western diet consumption impairs memory function via dysregulated hippocampus acetylcholine signaling,” was authored by Anna M.R. Hayes, Logan Tierno Lauer, Alicia E. Kao, Shan Sun, Molly E. Klug, Linda Tsan, Jessica J. Rea, Keshav S. Subramanian, Cindy Gu, Natalie Tanios, Arun Ahuja, Kristen N. Donohue, Léa Décarie-Spain, Anthony A. Fodor, and Scott E. Kanoski.


 https://www.psypost.org/r .. oogle_vignette
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81 comments

 1 month ago '21        #2
Tlatoani  topics gone triple plat - Number 1 spot x1
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I think what's most alarming about this finding is that not only are the diets bad for memory, but our habits and behaviors with the advent of modern technology is also bad for our memory.

Our devices do most of the remembering for us and the COVID online learning years were a complete waste.

If you're someone with a bad diet since early childhood who is addicted to their phone AND you're not engaged at school, your brain is basically shriveled up by 18.
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 1 month ago '11        #3
Tony Franks  topics gone triple plat - Number 1 spot x2
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right, and they lace our water with a dangerous chemical that also fu#ks with our cognitive functioning.
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 1 month ago '10        #4
SandmanNyC 
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We are deliberately being poisoned
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 1 month ago '21        #5
Tlatoani  topics gone triple plat - Number 1 spot x1
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 SandmanNyC said 🔗
We are deliberately being poisoned
It's deliberate, but it's for money.

The poisoning is mostly just a by-product of them chasing profits instead of some malicious plan to murder their customer base.

Capitalism for ya.
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 1 month ago '11        #6
Sin  topics gone triple plat - Number 1 spot x71
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 SandmanNyC said 🔗
We are deliberately being poisoned
who is deliberately doing it?




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 1 month ago '18        #7
Dehone 
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This reversibility of microbiome alterations, however, did not extend to the cognitive impairments, which persisted despite the dietary switch.

That’s alarming
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 1 month ago '14        #8
longliverick  topics gone triple plat - Number 1 spot x1
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That’s the least of the problems of a western diet
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 1 month ago '07        #9
yola  topics gone triple plat - Number 1 spot x91
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 SandmanNyC said 🔗
We are deliberately being poisoned
how? there are no laws against buying and selling unprocessed food, every store has them

christian capitalism is the culture that spends billions of dollars influencing people to eat the wrong things

if you don't like sh1t food, you don't like capitalism
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 1 month ago '07        #10
yola  topics gone triple plat - Number 1 spot x91
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these studies remind me of a guy i went to high school with

he let his daughters fu#k off their sleep, bought them fast food regularly and always had sh1t food around the house

then he couldn't understand when the first one got diabetes
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 1 month ago '07        #11
yola  topics gone triple plat - Number 1 spot x91
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 Tlatoani said 🔗
If you're someone with a bad diet since early childhood who is addicted to their phone AND you're not engaged at school, your brain is basically shriveled up by 18.
it gets even scarier when you add in poor sleeping habits
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 1 month ago '21        #12
Tlatoani  topics gone triple plat - Number 1 spot x1
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 yola said 🔗
it gets even scarier when you add in poor sleeping habits
Fortnite all nite
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 1 month ago '22        #13
zerogate  topics gone triple plat - Number 1 spot x5
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Folks been saying this for years but get dismissed as 'conspiracy theorists'.
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 1 month ago '16        #14
Ghostface Killa  topics gone triple plat - Number 1 spot x3
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 Sin said 🔗
who is deliberately doing it?

↪🔗

↪🔗
Something to give Biden credit for
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 1 month ago '11        #15
Sin  topics gone triple plat - Number 1 spot x71
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 Ghostface ki1la said 🔗
Something to give Biden credit for
He hasn’t been the most likable but i can’t see how anyone could disagree with having clean water
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 1 month ago '16        #16
Ghostface Killa  topics gone triple plat - Number 1 spot x3
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 Sin said 🔗
He hasn’t been the most likable but i can’t see how anyone could disagree with having clean water
Yeah, and actually engaging the EPA

It's wild to me that the EPA, FDA and Education systems affect so much of our society yet are an afterthought at best when it comes to our presidents.

Our food poisons is because the presidents don't do anything about it. Same with water and poor education.

I could fix education day 1 in office.
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 1 month ago '11        #17
Tony Franks  topics gone triple plat - Number 1 spot x2
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 Tlatoani said 🔗
It's deliberate, but it's for money.

The poisoning is mostly just a by-product of them chasing profits instead of some malicious plan to murder their customer base.

Capitalism for ya.
2 birds, one stone. The corportion wants money but the elites above them definitely want to keep our numbers low, through sickness and sterilization.

So if they find something cheap to substitute for real food, or find a new toxic fertilizer or pesticide, they are only gonna make sure they figure out how much they can use without ki1ling us immediately, and the govt will sign off.

They got all these migrants flooding in for a reason.

 1 month ago '11        #18
Sin  topics gone triple plat - Number 1 spot x71
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 Ghostface ki1la said 🔗
Yeah, and actually engaging the EPA

It's wild to me that the EPA, FDA and Education systems affect so much of our society yet are an afterthought at best when it comes to our presidents.

Our food poisons is because the presidents don't do anything about it. Same with water and poor education.

I could fix education day 1 in office.
Chicago crime could be fixed in a decade







fu#k Ukraine and Israel let’s get our kids clean water at the least
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 1 month ago '21        #19
Tlatoani  topics gone triple plat - Number 1 spot x1
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 Tony Franks said 🔗
2 birds, one stone. The corportion wants money but the elites above them definitely want to keep our numbers low, through sickness and sterilization.

So if they find something cheap to substitute for real food, or find a new toxic fertilizer or pesticide, they are only gonna make sure they figure out how much they can use without ki1ling us immediately, and the govt will sign off.

They got all these migrants flooding in for a reason.
The elites gain nothing from the theory you proposed. There is no benefit for them from doing this. Their businesses would suffer from a depression of the labor force and the instability brought to infrastructure as a result of ma$s depopulation and illness.

If this is true, what are they gonna do when they get tired of the incoming migrants?

Poison them too and start recruiting migrants from Papa New Guinea to replace them? Mars?
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Last edited by Tlatoani; 04-18-2024 at 09:36 AM..

 1 month ago '21        #20
loveeveryday  topics gone triple plat - Number 1 spot x20
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We learn about this somewhat in anatomy cla$s

From my personal experience fasting can solve a lot of this

The thing is tho most people are addicted to food so they will never commit to fasting and it’s benefits
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 1 month ago '19        #21
zzxxccvvbb 
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"western diet" = fat, dumb and ret@rded diet

The only people I know that eat like that I think of as a step above teenagers in mental faculties
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 1 month ago '04        #22
jholla31  topics gone triple plat - Number 1 spot x3
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Intriguing

 1 month ago '17        #23
QdobaCasanova 
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 SandmanNyC said 🔗
We are deliberately being poisoned
Brain dead take. You live in a hyper capitalistic society; you make less money with less people.

Why would “they” want to make less money, dingus.

You’re a shining example of the Western diet slurpee-fying brains
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Last edited by QdobaCasanova; 04-18-2024 at 09:54 AM..
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 1 month ago '23        #24
LowCountrySC 
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ok and?

do one on the EU now.

like do yall even know america isnt even in the top 10 highest cancer rates in the world? but our diets are ki1ling us.
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BX has turned into a cesspool of ret@rdation and misinformation for likes. ronnie should have never banned the gang wars that summer, that sh1t was cleaning up all the stormfront trolls but nooooooo he decided they were worth more to the site than OGs. look at it now MAGA halfworld
+1   

 1 month ago '12        #25
Binds 
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I need to get my diet right for my future self asap
+1   

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