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Sep 19 - The End Of Aging: Are You Ready To Live To 150?


 
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 4 weeks ago '06        #1
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Sep 19 - The End Of Aging: Are You Ready To Live To 150?
 

 
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Harvard's genetics genius says we can live past 120 with supplements and lifestyle tweaks. Prepare to meet your future descendants.



Dear 22nd Century,

In my letters up to this point, I’d kind of a*sumed I was writing to distant descendants. The babies of this decade will be the eightysomethings of the early 2100s; most of the denizens of the next century are generations unborn at press time. And nearly all of the rest of us are just ghosts. Long gone. Food for worms. Pushing up daisies or blowing in the wind. Ashes to ashes and all that, right?

Not so fast. It turns out humanity’s understanding of its aging process (and how to stop it) is advancing more rapidly than anyone expected. So rapidly, in fact, that some of the planet’s top biologists believe we can hold back the tide of aging, starting now, with today’s drugs and supplements and diets and exercises, just as soon as the medical establishment starts to see aging as a treatable disease. And that means it’s distinctly possible that one of the people I’m writing to in the dawn of the 22nd century is ... myself.

In which case, hello future me! First question: Just how wild did things get at our 127th birthday party?

You may recall that in 2019, the idea of anyone living to that age sounded absurd; doing so in good health even more so. We were still stuck in the mindset that the Bible-mandated threescore-and-ten was what constituted a long life. If you made it to 70 or 80 with your health intact, well, that was about the best you could hope for. The decline would start to kick in then, hastened by one of the diseases that become more likely as we age: Alzheimer’s, heart disease, the big C. With genetic luck, a good diet and reasonably deep pockets, you could make it to 90. With really good fortune you could become one of those grinning centenarians on the local evening news — gone a hundred rounds in the ring with the ravages of time, but happy to still be around to eat cake and wear silly hats, even if you had to wheel yourself away from the table for your medication and afternoon nap afterwards.

Once you passed 110, you almost shaded into myth. In 2019 the world’s oldest living person, Kane Tanaka of Japan, is 116. The current world record was set by Jeanne Calment, who died in 1997 at the age of 122 — and despite accusations from one gerontologist that Calment’s daughter had secretly taken her place during the chaos of World War II, 122 is still what scientists think of as the outer limit of human lifespan.

I have long been obsessed with seeing as much of the future as I possibly can. And yet the most optimistic wish I’d ever made for myself is that I might be lucky enough — and still in control of enough of my faculties — to see what the world has made of itself on my 100th birthday, in the far-off 2070s. Then in September 2019, a Harvard professor of genetics told me the following: “By the turn of the next century, a person who is 122 on the day of his or her death may be said to have lived a full, though not particularly long, life. We will look back with sadness on the time in our history in which it was not so.”

The professor, who is currently 50 but looks about 30, says he will hopefully live to see 2100 himself, at which point he will be 132. Instantly, that made me insanely competitive: If he can do it, at a more advanced age, so can I!
"By the turn of the next century, a person who is 122 on the day of his or her death may be said to have lived a full, though not particularly long, life."

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The professor’s name is David Sinclair, award-winning scientist and author of the new book Lifespan: Why We Age and Why We Don’t Have To. Sinclair, who recently became a minor celebrity via one of our culture's latest avenues to fame, a two-hour conversation on the Joe Rogan Experience, is hardly our culture’s first longevity guru. I’m old enough to remember 2004, when inventor Ray Kurzweil began touting the idea that we could live forever if we just held on until the mid 2020s, by which time advanced biotech (and the Singularity, the term Kurzweil popularized for the moment AI becomes smarter than us) would take over, somehow.

Kurzweil soon became known in Silicon Valley for his giant ziploc baggies of vitamins and supplements, which he took several times a day in the hope of sticking around for the Singularity. He liked to quote longevity researcher Aubrey De Grey, who deals in a still hypothetical field called regenerative medicine, making this typically wild pronouncement: That by 2100, “life expectancy will be in the region of 5,000 years.”

Sinclair isn’t like that. A soft-spoken Australian (a rarity in itself) who chooses his words very carefully, he doesn’t claim we can live forever or see the year 7100 — just that large numbers of us should be able to push past the 122-year barrier, into uncharted territory, and that living until 150 is “not a silly thing to dream about.”


Unlike Kurzweil and de Grey, Sinclair has actually done the biological work. Most of his awards were for figuring out the aging mechanism in yeast, but he has also expanded the lives of laboratory mice. In one of his favorite experiments, a geriatric mouse ran nonstop for so long that it broke the lab treadmill, which wasn’t built to go more than 3 kilometers — an ultramarathon for rodents.

So when Sinclair says that “aging is easier to cure than cancer” — and that if we cure aging, we will minimize cancer’s harm — it’s worth sitting up and listening. He has the receipts. The first third of his book is a dense slog through the genetic science and his “information theory of aging,” which basically says that our cells break down because they make increasingly poor analog copies of themselves, like cassette tapes recording from cassette tapes. (22nd century kids, ask anyone over 110 what a cassette tape was.)

The DNA in each cell gets frayed. The cell walls get weak and begin to collapse. All our cells were once stem cells and are supposed to have settled down into one form — a heart cell, a skin cell, a brain cell. As we age, some start to climb back up the hill towards being a stem cell again, but they can’t get all the way there and simply jump the groove into being another kind of cell, like a needle skipping on a record player (ask anyone over 120 about record players).

That can cause tumors, collapsed capillaries, and other horrific cellular mistakes. “This loss of information is what leads each of us into a world of heart disease, cancer, pain, frailty and death,” says Sinclair. We can’t yet get our cells to make lossless digital copies of themselves. But we should be able to treat copying errors “like scratches on a CD,” Sinclair says, completing a trifecta of 20th century recording media analogies. (Anyone over 100 should be able to tell you what a CD was, and that scratches didn’t matter if you wiped it down.)

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How do we do that? Well, what Sinclair confirmed with that treadmill mouse, and other experiments, was that enzymes called sirtuins can boost the strength of cells so much that they stop skipping the groove. And that you can activate sirtuins with a “helper molecule” called NAD. The senior citizen mouse had so much NAD in its system that its blood vessels were healthy and young, full of delicious oxygen, and it evidently felt like running forever.

There are many ways to make more NAD in the body. (This is probably grade school biology for you, but gramps just learned how it all works, so bear with me.) A lot of expensive drugs and supplements promise to boost it. But I was surprised to discover that the one Sinclair now favors, NMN — Nicotinamide mononucleotide, if you’re feeling formal — is just sitting there all over the internet, hiding among thousands of useless supplements in plain sight, like the Ark of the Covenant in the warehouse at the end of Raiders of the Lost Ark.

NMN, derived from the B vitamin niacin, is not the world’s cheapest supplement, but it’s hardly out of reach. I got a month’s supply for under $20. That’s at a dose of 250 mg a day; Sinclair himself takes a full gram of NMN every day, mixed into his yogurt, so to match him I’ll have to spend $20 a week. Still, that’s a decent investment if it saves me from having to shell out for massive doses of age-related disease-f*ghting drugs down the line. Besides, what price can you put on more life?

There’s been an explosion of research in the last few years showing that NMN (and its chemical cousin NR) may be a fountain of youth. But the stuff that sticks with me is the personal anecdotes. Sinclair started giving it to his father when his dad was 70, had just lost his wife, and was anticipating a slow decline; he’s now 80, going on dates and international flights and hiking such long distances that Sinclair can barely keep up. Sinclair also started giving NMN to his 10-year-old poodle crossbreed Charlie, who worked as a therapy dog in hospitals — but no more, because the invigorated pup now has too much energy to sit still for patients.

Even just taking NMN for a week, I started to feel the bracing effects — like a triple shot of espresso, but longer-lasting and less speedy. My wife has suffered from chronic fatigue for years, but NMN has started to pull her out of it. (This would be a good point to note that some people get a mild nausea reaction from NMN, but that neither NMN nor NR have that uncomfortable flushed face effect that raw niacin is known for.)


NMN isn’t the only supplement Sinclair takes or recommends. There’s also resveratrol, a compound found in red wine. We’ve known for some years that resveratrol reduces blood pressure; turns out it also boosts NAD. (For a long time we thought resveratrol was beneficial because it was an antioxidant, but biologists like Sinclair have started to shy away from the oxidizing theory of aging.) And then there’s Metformin, one of the most widely-used diabetes drugs, which has also been shown to have anti-aging properties.

Our general practitioners won’t currently prescribe it for aging, however, because they don’t see it as a disease, because a disease by definition is not something that affects the whole population. Sinclair believes they’ll catch on eventually, once the latest scientific literature filters down.

The Benjamin Button virus
There are other brand new drugs in the works, many of which Sinclair can’t talk about, that he says “will make what we have today look like doctors using leeches.” But he does predict that within the next few decades, doctors will start injecting us with a benign designer virus that can literally reprogram our genome to be young again. You'd take a course of injections around age 30, then when you start to feel the effects of aging in your mid-40s, a course of antibiotics will wake the virus up.

That would turn on genes that would literally turn the clock back on your body -- un-graying hair, removing wrinkles, even regenerating organs. "Like Benjamin Button, you would feel 35 again, then 30, then 25," Sinclair writes. At that point, you take a second antibiotic to turn off the fountain of youth lest it reverse aging too far.

"Does that sound like science fiction?" asks Sinclair. Why yes it does, to us. But very likely not to you.

It’s not all drugs and futuristic therapies. There are two other ways to help f*ght aging that everyone in my era should be doing, and they know exactly what they are. You probably do too. Say it with me now: diet and exercise.

The exercise part is less onerous than most people think. Just half an hour of heartrate-raising activity on a regular basis has massively beneficial effects (maybe even more so than working out for an hour, possibly because you're left with more energy to burn more calories). Sinclair himself only works out once or twice a week, going for a run and doing weight training with his son. He also exercises his body in the sense of exposing it to extreme temperatures — in his case, saunas, cold plunges, and T-shirt runs in the Boston snow — which have also been shown to increase lifespan in lab creatures.

Much of the anti-aging process, it seems, involves putting just the right amount of stress on the organism, so the organism bounces back tougher than ever.




visit this link https://mashable.com/feature/aging/
+8   



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72 comments
 

 4 weeks ago '04        #2
SubConscious  54 heat pts54
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No.

I'm already tired, and ready to go.

Exhausted with humans.
+48   

 4 weeks ago '14        #3
Ivorypillars  16 heat pts16
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+14   

 4 weeks ago '17        #4
Hakeem  3 heat pts3
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.......

 4 weeks ago '05        #5
Micheal C. Will  41 heat pts41
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Sure why not, if I'm healthy and able bodied.

sh*t I'll take immortality if it was possible.

I'm sure the slaps are coming from the miserable, pessimistic individuals who probably don't even want to live to be 40
+23   

 4 weeks ago '18        #6
Demonmarcus 
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Lol we'll be back to experience this. This life we're living is just one of many
+13   

 4 weeks ago '14        #7
Hoodsta1e11  5 heat pts5
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Hell naw they trying to use this to fix the ssi problem naw I want my doe and retirement
+11   

 4 weeks ago '17        #8
Faseforeal1  2 heat pts2
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I'll pass. Dont want to end up like her.


+19   

 4 weeks ago '05        #9
Avenger772  15 heat pts15
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As long as I can still take care of myself and have all my facalties. No reason to live that long and be a fu*king vegetable.
+20   

 4 weeks ago '18        #10
dacoolestg 
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history repeats itself
+2   

 4 weeks ago '11        #11
Sin  topics gone triple plat - Number 1 spot x2
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Who has retirement funds to last 85 years after retirement?


Last edited by Sin; 09-20-2019 at 07:31 AM..
+27   

 4 weeks ago '17        #12
lucifershammer  29 heat pts29
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Meh til they upload minds to nternet

I want that ghost in the Shell lifestyle
+2   

 4 weeks ago '06        #13
d4deesnuts  3 heat pts3
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 Faseforeal1 said
I'll pass. Dont want to end up like her.

@ 3:52
+3   

 4 weeks ago '12        #14
OldBusiness  193 heat pts193
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Nah im cool with hitting 75-80 and checking out.
+9   

 4 weeks ago '17        #15
Rugged 
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A healthy 120, why not? ....

But it ain't gonna happen with the all the 5G and nnEMF we got poppin'...


+11   

 4 weeks ago '05        #16
bi0  7 heat pts7
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Unless your rich AF it’s kinda pointless to continue to live past 90.
+6   

 4 weeks ago '15        #17
naledgestate 
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If i cant get my sick ducked at 100... that wouldnt be a help.



+23   

 4 weeks ago '19        #18
925  4 heat pts4
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Looking to see if this NAD stuff is fat soluable probably would be more powerful in a liposome.
+1   

 4 weeks ago '19        #19
sinsay 
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 Faseforeal1 said
I'll pass. Dont want to end up like her.

Bruh
"Are you excited for your party?"
"Not one bit"

+3   

 4 weeks ago '15        #20
PolygonMafia  4 heat pts4
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Meh, idk, depends how ridiculous this current reality gets. I feel like this will be limited to rich people. Don’t know how or why, just my gut feeling.

New retirement age gonna be 100 in a bit anyways
+4   

 4 weeks ago '14        #21
strungout  topics gone triple plat - Number 1 spot x1
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i wish i can stay 28 years old forever i feel like I'm at my prime right now
+9   

 4 weeks ago '19        #22
Mr Insecurity  2 heat pts2
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 Sin said
Who has retirement funds to last 75 years after retirement?
And this is the point. With life expectancy currently into the late 70s, most folks are looking to survive about 15 years into their retirement. Smart planning and you shouldn't outlive your money.

How does one manage a retirement period that long (75 years)?

Or...people are going to have to extend their highest earning years beyond their 100th birthday.
+1   

 4 weeks ago '18        #23
danneywilliams  93 heat pts93
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This NMN/resveratrol stuff sounds great, but if the effects were significant, why do we still have rich folks who are old and sick?

 4 weeks ago '19        #24
Mr Insecurity  2 heat pts2
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. Those industries have, by far, the most employees in them. Imagine being a 2nd grade teach for 70 years (or more) because you're going to have to stay in the game a long time to earn a large enough pension to sustain you for the 60 years that you're retired.

Some (most) professions are not conducive to careers that long.

suicides among the elderly are going to skyrocket.
+1   

 4 weeks ago '08        #25
GoldBluded  topics gone triple plat - Number 1 spot x1
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 strungout said
i wish i can stay 28 years old forever i feel like I'm at my prime right now
While listening to a YouTube video i heard in the next 15 years they will achieve some supplemental hormone or dna fixture that will allow people to age in reverse.
+4   



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