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May 18 - Being Socially Isolated for Long Periods of Time Reshapes Brain Chemistry


 
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 10 months ago '17        #1
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Enigmatic1 342 heat pts342
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May 18 - Being Socially Isolated for Long Periods of Time Reshapes Brain Chemistry
 

 
But the pain of loneliness may have a remedy.


Being lonely sucks. Sure, we all need our alone time now and then, but scientists have repeatedly found that, as social animals, prolonged loneliness is bad for us. In 2016, visit this link scientists found the physical locus of loneliness in the brain, and now, as research on this eternal human affliction continues, scientists have discovered that the stress of chronic social isolation can actually reshape the brain.

Whereas much of the research on isolation and stress involves behaviors, the Cell paper, published Thursday, looks at a lesser-studied factor: the brain chemicals involved in loneliness. It showed that mice experiencing the stress of spending two weeks in social isolation had elevated levels of a brain-signaling molecule called Tac2, which in turn increases levels of a neuropeptide called NkB. The abundance of this molecule, the researchers write, might be responsible for all of the stressed-out behaviors they noticed in the mice. “It’s a neuropeptide that’s conserved across a number of species, and at least in mice and fruit flies, it seems to be involved in some aspects of social isolation,” Moriel Zelikowsky, Ph.D., a neuroscience postdoc at Caltech and the first author on the new study, tells Inverse. Human brains have very similar pathways to those of mice, which suggests that the findings will hold true for us, too.

The signs of stress the isolated mice exhibited included higher levels of anxiety and exaggerated responses to potential threats. Further supporting the hypothesis that Tac2 and NkB are to blame, the study’s authors showed that mice who were given a drug that inhibits the action of those molecules did not show signs of isolation stress under the same circumstances. To put it simply, this study shows evidence that there are chemical changes in the brains of mice that experienced long-term social isolation — and, importantly, that these changes can be blocked.

“It’s definitely in a position to be readily translatable to humans for targeted therapies,” Zelikowsky says, explaining that the antagonist drug the team gave the mice during their periods of isolation effectively lessened the negative effects of the isolation. This suggests that, while the effects of loneliness show up as psychological stress, they can be managed with neuroscience and pharmacology.

Zelikowsky says that a therapy like this one, which targets only a single type of brain receptor, could eventually be much more effective and cause fewer side effects than drugs like the currently available antidepressants, which act on huge systems in the brain. She sees this research as particularly relevant now, with increasing levels of social isolation among young people and old people alike.

“Much like they’re trying to target cancer drugs to just cancerous cells,” she says, “this could target a specific subset of cells producing abnormal behaviors, some of which are detrimental to the quality of life we’d all like to have.”

100 comments for "May 18 - Being Socially Isolated for Long Periods of Time Reshapes Brain Chemistry"

 10 months ago '17        #2
QdobaCasanova 12 heat pts12
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70% of bx

 10 months ago '07        #3
Damagegadget 494 heat pts494
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Ive grown old and as a bachelor whos friends have all had kids and spouses...im not sure how its changed me, but I realize more and more how fake people are lol..outside lookin in perspective is amazing

 10 months ago '15        #4
The Flyin Lion 155 heat pts155
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 QdobaCasanova said
70% of bx
Word, you can tell who's crazy cause some dudes make threads arguing with themselves. they'll state an opinion then write like 3 paragraphs to back it up arguing with no one. HHS and SC are full of em

 10 months ago '06        #5
Qbert 25 heat pts25
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I'm not one to go to the club and things like that, so if I didn't have a home life, my mind would definitely be slipping.

I could see that being the case with a lot of people, they fall through the cracks of society.

 10 months ago '17        #6
509 12 heat pts12
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source? :kobeuserious:


Last edited by 509; 05-18-2018 at 07:46 PM..

 10 months ago '04        #7
J. Snuffuhnigga 
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And then you think of how ppl in jail/prison are put into isolation. RIP kalief browder rest easy young king

 10 months ago '06        #8
illathruz 77 heat pts77
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Slapped for posting an article from 2016

 10 months ago '08        #9
flav 2 heat pts
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 illathruz said
Slapped for posting an article from 2016
err... so that makes it invalid ?

 10 months ago '04        #10
Miami 9 heat pts
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i like being alone from time to time

 10 months ago '18        #11
Oswaldgatesjr 16 heat pts16
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 Miami said
i like being alone from time to time

Keyword from time to time.

 10 months ago '11        #12
Joseph 14 heat pts14
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Scientists should research something useful once in awhile. Go cure cancer or some sh*t.

 10 months ago '12        #13
CaLis LEGACY 83 heat pts83
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Loneliness ain't a joke that sh*t is deadly and can fu*k with ur head.

 10 months ago '17        #14
KingBud 1 heat pts
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 mikerizzy said
Alone > than a crowd..

i'm a black man with money in a economically depressed area, i get no satisfaction being social.
This..

 10 months ago '05        #15
P-Hill|M 28 heat pts28
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 509 said
it's too late for me i'ma k*ll everybody
whether you joking or not, I sent your IP address to the feds you ain't about to cause another tragedy in this country Not on my watch

 10 months ago '07        #16
Chief|m 61 heat pts61
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 509 said
it's too late for me i'ma k*ll everybody
reported

 10 months ago '06        #17
ChrisStokes 106 heat pts106
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i want me a bad philiipino chick that speaks mandarin and english and calls me pappy when we making love!

 10 months ago '05        #18
blah blah blah 96 heat pts96
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[video - click to view]


Most convos w other ppl is “mindless droning”

 10 months ago '16        #19
3LIT3 
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 Damagegadget said
Ive grown old and as a bachelor whos friends have all had kids and spouses...im not sure how its changed me, but I realize more and more how fake people are lol..outside lookin in perspective is amazing
Fake how you talking bout us homies growing up or something?

 10 months ago '10        #20
Big Louie Guwop 161 heat pts161
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 QdobaCasanova said
70% of bx
At least 85%

 10 months ago '04        #21
skillahmang 3 heat pts
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 10 months ago '05        #22
barber 
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“Netflix and Contented

Sometimes it is hard being in a relationship when all you want to do is watch Netflix and chill.
My girlfriend keeps telling me I need to get out more and meet some new people since I work from home.
We have a conflict of interest because she wants to go out on the town over the weekend instead of getting more takeaway and watching something on Netflix.
My girlfriend gets angry, and she starts yelling at me, trying to alter my tedious ways.
I wish to live a simple and quiet life, minding my own business, but my girlfriend wants the lifestyle of a socialite.
My girl likes to watch reality TV, especially the Kardashians, and she enjoys taking notes from their glamorous lifestyle.
I watch the news channels, seeing all the devastation unfolding around the world, and I tell my girlfriend it doesn’t pay to be out and about all the time.
I start clashing with my girl because she’s more of a gregarious person, but I have become more introverted over the years.
I am contented with the simple things in life, like having a cup of coffee in the morning and reading[…]”

Excerpt From
Food for Thought
Duane Ashley Poole

This material may be protected by copyright.

 10 months ago '07        #23
No Notoriety 105 heat pts105
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Blame my parents. I thought it was called being a sociopath.

 10 months ago '18        #24
KingBossHellBoy 120 heat pts120
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boredom will make u crazy

 10 months ago '07        #25
Damagegadget 494 heat pts494
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thing is most artist and especially DJ's who actually hone their skill, spend their time alone

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