Damn some of these video titles are major spoilers.
This cut scene in Mafia 2 after
[spoiler - click to view]
The ending of Halo: Reach was dope. Especially if you played the first 3 (which took place after Halo: Reach). Video contains the ending, so spoiler alert.
And, the ending of Mass Effect 2 was already posted, but this cutscene immediately preceding the final mission was made to be epic, and it was the closest thing to perfected cinematic feel in videogame history in my opinion (If you played through both the first and second ones I feel you'd rank it at least in your top 5), I had this s**t blasted high as f**k on my surround sound, had me pumped as f**k to do this mission. Just to f**king dope. The fact that you are making game changing decisions during the cutscene (Who to send on the stealth mission, who to lead the other squad, etc.) Watch in 720 P if you can.