Aug 24 - Protein that destroys HIV discovered - HIV VACCINE FOUND?

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 8 years ago '04        #1
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Exs 159 heat pts159
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Aug 24 - Protein that destroys HIV discovered - HIV VACCINE FOUND?
 

 
Loyola University researchers have identified the key components of a protein called TRIM5a that destroys HIV in rhesus monkeys.

The finding could lead to new TRIM5a-based treatments that would knock out HIV in humans, said senior researcher Edward M. Campbell, PhD, of Loyola University Health System.

Campbell and colleagues report their findings in an article featured on the cover of the Sept. 15, 2010 issue of the journal Virology, now available online.

In 2004, other researchers reported that TRIM5a protects rhesus monkeys from HIV. The TRIM5a protein first latches on to a HIV virus, then other TRIM5a proteins gang up and destroy the virus.

Humans also have TRIM5a, but while the human version of TRIM5a protects against some viruses, it does not protect against HIV.

Researchers hope to turn TRIM5a into an effective therapeutic agent. But first they need to identify the components in TRIM5a that enable the protein to destroy viruses. “Scientists have been trying to develop antiviral therapies for only about 75 years,” Campbell said. “Evolution has been playing this game for millions of years, and it has identified a point of intervention that we still know very little about.”

TRIM5a consists of nearly 500 amino acid subunits. Loyola researchers have identified six 6 individual amino acids, located in a previously little-studied region of the TRIM5a protein, that are critical in the ability of the protein to inhibit viral infection. When these amino acids were altered in human cells, TRIM5a lost its ability to block HIV-1 infection. (The research was done on cell cultures; no rhesus monkeys were used in the study.)

By continuing to narrow their search, researchers hope to identify an amino acid, or combination of amino acids, that enable TRIM5a to destroy HIV. Once these critical amino acids are identified, it might be possible to genetically engineer TRIM5a to make it more effective in humans. Moreover, a better understanding of the underlying mechanism of action might enable the development of drugs that mimic TRIM5a action, Campbell said.

In their research, scientists used Loyola’s wide-field “deconvolution” microscope to observe how the amino acids they identified altered the behavior of TRIM5a. They attached fluorescent proteins to TRIM5a to, in effect, make it glow. In current studies, researchers are fluorescently labeling individual HIV viruses and measuring the microscopic interactions between HIV and TRIM5a.

[pic - click to view]

 http://www.loyolamedicine .. e_id=973441241


[pic - click to view]

 Protein that destroys HIV discovered | KurzweilAI

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60 comments for "Aug 24 - Protein that destroys HIV discovered - HIV VACCINE FOUND?"

 08-24-2010, 12:11 AM         #2
x7eflon 
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when i see it on CNN or Fox news & i see it work I don't believe it
 8 years ago '07        #3
infamxus 12 heat pts12
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reserved.
 08-24-2010, 12:18 AM         #4
Lex Lossis 
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 x7eflon said:
when i see it on CNN or Fox news & i see it work I don't believe it
so did the bar code tattoo on your neck hurt??


Last edited by Lex Lossis; 08-24-2010 at 12:25 AM.. Reason: neck not back lol
 8 years ago '04        #5
Exs 159 heat pts159 OP
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 Lex Lossis said:
so did the bar code tattoo on your back hurt??


 08-24-2010, 12:23 AM         #6
k3llz 
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 Blood Edge said:
it's not breaking news....ask Magic Johnson
real talk...only rich f**kas can get it
 8 years ago '06        #7
SpeedLimits65 5 heat pts
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i thought they found it a couple of years ago. you just have to inject about $10,000 in liquid form into your veins
 8 years ago '04        #8
Exs 159 heat pts159 OP
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 Kain said:
[EVIL]Humans also have TRIM5a, but while the human version of TRIM5a protects against some viruses, it does not protect against HIV.[/EVIL]


YOU DIDN'T ACTUALLY READ THE ARTICLE

THEY WERE TALKING ABOUT MONKEYS

[EVIL]In 2004, other researchers reported that TRIM5a protects rhesus monkeys from HIV. The TRIM5a protein first latches on to a HIV virus, then other TRIM5a proteins gang up and destroy the virus.[/EVIL]





HIV is the SAME disease in monkeys as it is in humans...
 8 years ago '04        #9
Exs 159 heat pts159 OP
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 Kain said:


SORRY DOGGIE. NICE TRY THOUGH.
Boy Oh Boy... You really are a doomer arent you... I thought your "Based God" preached positivity and optimism... apparently not...

OF COURSE

SIV in not HIV

the H in HIV stands for HUMAN

the S in SIV stands for SIMIAN (monkeys, chimps etc)



any more wikipedia links... so typical

gtfo


Last edited by Exs; 08-24-2010 at 12:46 AM..
 08-24-2010, 12:46 AM         #10
x7eflon 
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 Lex Lossis said:
so did the bar code tattoo on your neck hurt??
lol can't lie thats a good one

plus im bein sarcastic
 8 years ago '05        #11
EastBroadway 35 heat pts35
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 Supa Mario 910 said:
You'll never hear about this story again...
I Agree.
 8 years ago '04        #12
Exs 159 heat pts159 OP
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 Kain said:



BETTER SOURCE
umm the research was done @ Loyola University (thats a 4 year school )




your doin this to yourself... and are a perfect example of why

INTELLIGENCE ALWAYS WIN


:dancingcool::dancingcool::dancingcool:














btw

I'm GOD
 8 years ago '10        #13
Big Louie Guwop 133 heat pts133
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n*gga they had a cure since like the 60's or some s**t like that
 8 years ago '04        #14
Exs 159 heat pts159 OP
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 Kain said:
Save everyone from a big let down and edit your thread title, CLOWN.

:applause:
:sad5:

oh we've resorted to name calling now..

You sir are a peasant and unworthy of a reply..

Obviously God has not blessed you in this life... and for that i apologize...

You have permission to k!ll yourself
 8 years ago '04        #15
Adwerdz 348 heat pts348
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vaccines are the reason why HIV exists

f**king scientists
 8 years ago '05        #16
Y.G. 27 heat pts27
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This sounds a little more promising.

 8 years ago '04        #17
Exs 159 heat pts159 OP
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 younggangsta_s said:
This sounds a little more promising.

That Was Sunday...


It is now Tuesday...


God works fast dont he



 8 years ago '04        #18
Exs 159 heat pts159 OP
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 Kain said:
THAT WASN'T POSITIVE.

WE ALL MAKE MISTAKES
i was only trying to show you a way out of this place you condemn so much inside.... im here to alleviate your stresses... and if bringing you POSITIVE news doesnt do that... then i resort to using negativity since its something you seem to respond to..

now



get the knife :grin2:
 8 years ago '06        #19
tpoker 3 heat pts
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man of all the people in this world, 1 person has to have a natural immunity to it and im pretty sure they found the cure thru this person long ago.
 8 years ago '05        #20
Y.G. 27 heat pts27
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 dragswizz said:
That Was Sunday...


It is now Tuesday...


God works fast dont he





Those are 2 different treatments.
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