I think wes could knock out another blade movie. blade does age like a human if i remember correctly from the first movie. So having a older and more gray looking wesley snipes as blade could fit in if written correctly.
Maybewe find out him and Karen from the 1st blade had had s3x and she gotten pregnant at some point while she was there with him and whistler. That could be a nice li l way to bring the daughter he was supposed have. then it could move wesley towards mentor role like whistler was to him.
But even Wes plays Blade again or not i just hope they say blade trinity isnt canon anymore. I fu*king hated that garbage. The 1st 2 movies is the GOAT vampire slayer movies tho.